What's Wrong With MY Mysql

I have a mysql-only server and the server is constantly > 30 in server load. I'm ousted as to what is wrong with mysql and what can be done to optimize it. Using mysql report to generate the following:

Quote:

MySQL 4.1.22-standard uptime 0 0:22:30 Thu Feb 22 07:14:45 2007

__ Key _________________________________________________________________
Buffer used 30.93M of 256.00M %Used: 12.08
Current 60.41M %Usage: 23.60
Write ratio 0.891
Read ratio 0.001

__ Questions ___________________________________________________________
Total 416.13k 308.2/s
DMS 136.54k 101.1/s %Total: 32.81
Com_ 120.17k 89.0/s 28.88
COM_QUIT 117.10k 86.7/s 28.14
QC Hits 44.35k 32.9/s 10.66
-Unknown 2.04k 1.5/s 0.49
Slow 19 0.0/s 0.00 %DMS: 0.01
DMS 136.54k 101.1/s 32.81
SELECT 82.50k 61.1/s 19.82 60.42
UPDATE 27.28k 20.2/s 6.56 19.98
REPLACE 10.85k 8.0/s 2.61 7.95
INSERT 7.98k 5.9/s 1.92 5.84
DELETE 7.93k 5.9/s 1.91 5.81
Com_ 120.17k 89.0/s 28.88
change_db 119.37k 88.4/s 28.69
admin_comma 791 0.6/s 0.19
show_variab 3 0.0/s 0.00

__ SELECT and Sort _____________________________________________________
Scan 6.38k 4.7/s %SELECT: 7.73
Range 6.35k 4.7/s 7.70
Full join 0 0/s 0.00
Range check 0 0/s 0.00
Full rng join 0 0/s 0.00
Sort scan 3.99k 3.0/s
Sort range 9.92k 7.4/s
Sort mrg pass 1.27k 0.9/s

__ Query Cache _________________________________________________________
Memory usage 5.85M of 32.00M %Used: 18.28
Block Fragmnt 22.41%
Hits 44.35k 32.9/s
Inserts 75.31k 55.8/s
Insrtrune 75.31k:1 55.8/s
Hit:Insert 0.59:1

__ Table Locks _________________________________________________________
Waited 54.03k 40.0/s %Total: 31.44
Immediate 117.80k 87.3/s

__ Tables ______________________________________________________________
Open 763 of 1500 %Cache: 50.87
Opened 769 0.6/s

__ Connections _________________________________________________________
Max used 651 of 650 %Max: 100.15
Total 119.74k 88.7/s

__ Created Temp ________________________________________________________
Disk table 24 0.0/s
Table 3.75k 2.8/s
File 2.55k 1.9/s

__ Threads _____________________________________________________________
Running 106 of 132
Cached 36 of 128 %Hit: 96.43
Created 4.28k 3.2/s
Slow 4 0.0/s

__ Aborted _____________________________________________________________
Clients 5.28k 3.9/s
Connects 1.16k 0.9/s

__ Bytes _______________________________________________________________
Sent 2.03G 1.5M/s
Received 159.51M 118.2k/s

And my my.cnf

Quote:

[mysqld]
datadir=/var/lib/mysql
socket=/var/lib/mysql/mysql.sock
max_connections = 650
key_buffer = 256M
myisam_sort_buffer_size = 64M
skip-locking
join_buffer_size = 1M
read_buffer_size = 1M
sort_buffer_size = 1M
table_cache = 1500
thread_cache_size = 128
wait_timeout = 10
connect_timeout = 5
tmp_table_size = 128M
max_allowed_packet = 36M
max_connect_errors = 10
query_cache_limit = 1M
query_cache_size = 32M
query_cache_type = 1
max_user_connections =600
[mysql.server]
user=mysql
basedir=/var/lib

[mysqld_safe]
err-log=/var/log/mysqld.log
pid-file=/var/run/mysqld/mysqld.pid

[mysqldump]
quick
max_allowed_packet = 16M

[myisamchk]
key_buffer = 64M
sort_buffer = 64M
read_buffer = 16M
write_buffer = 16M

[mysqlhotcopy]
interactive-timeout