Reduce Packet Loss

I have smokeping monitoring my game servers and so far in the little time that it has been running all my game servers have been encountering an average of 4 to 10% packet loss. Are there are tweaks i can run on the server computer to reduce packet loss? (registry modifications, etc.)

I downloaded a TCP tweak program called "TCP Optimizer" is it safe to run on a Windows 2003 Server OS?

The colo connection is an OC 192 and i have a 100Mbit ethernet card.

Here are my current TCP settings:

Quote:

[SYSTEMCurrentControlSetServicesTcpipParameters]
TcpWindowSize=-1
GlobalMaxTcpWindowSize=-1
EnablePMTUDiscovery=-1
EnablePMTUBHDetect=-1
SackOpts=-1
DefaultTTL=-1
TcpMaxDupAcks=-1
Tcp1323Opts=-1
DisableUserTOSSetting=-1
DefaultTOSValue=-1
[SYSTEMCurrentControlSetServicesAfdParameters]
DefaultReceiveWindow=-1
[SoftwareMicrosoftWindowsCurrentVersionInternet Settings]
MaxConnectionsPerServer=-1
MaxConnectionsPer1_0Server=-1
[SYSTEMCurrentControlSetServicesICSharingSettingsGeneral]
InternetMTU=-1
[SOFTWAREMicrosoftWindowsCurrentVersionExplorerRemoteComputerNameSpace{D6277990-4C6A-11CF-8D87-00AA0060F5BF}]
{D6277990-4C6A-11CF-8D87-00AA0060F5BF}=-1
[SYSTEMCurrentControlSetServicesDnscacheParameters]
MaxNegativeCacheTtl=-1
NegativeCacheTime=-1
NetFailureCacheTime=-1
NegativeSOACacheTime=-1
[SOFTWAREPoliciesMicrosoftWindowsPsched]
NonBestEffortLimit=-5
[SYSTEMCurrentControlSetServicesTcpipServiceProvider]
LocalPriority=499
HostsPriority=500
DnsPriority=2000
NetbtPriority=2001
[SystemCurrentControlSetServicesLanmanServerParameters]
SizReqBuf=-1
[SYSTEMCurrentControlSetServicesNdisWanParametersProtocols]
ProtocolMTU=-2
[SYSTEMCurrentControlSetServicesTcpipParametersInterfaces{D63AC0FA-D2C9-4D83-B057-31A353516AB3}]
MTU=-1
TcpWindowSize=-1
[SYSTEMCurrentControlSetServicesPschedParametersAdapters{D63AC0FA-D2C9-4D83-B057-31A353516AB3}]
NonBestEffortLimit=-2
[SYSTEMCurrentControlSetServicesTcpipParametersInterfaces{8190D94A-3B2D-45C4-998D-312E99D6061D}]
MTU=-1
TcpWindowSize=-1
[SYSTEMCurrentControlSetServicesPschedParametersAdapters{8190D94A-3B2D-45C4-998D-312E99D6061D}]
NonBestEffortLimit=-2